Updated at 4:12 p.m. ET

The Trump administration Wednesday put forth a proposal that it labeled a "massive" tax overhaul, which would give big tax cuts to individuals and corporations and reduce the number of tax brackets and deductions.

Reporters and on-air personalities are among the roughly 100 ESPN employees who are expected to lose their jobs this week, in a cost-cutting move at the network that has lost millions of subscribers in recent years.

The annual TED conference is known for featuring impressive speakers. Attendees at this year's event in Vancouver have seen Serena Williams and Jorge Ramos, futurists and artificial intelligence experts, health activists and the ACLU's executive director.

But on Tuesday evening, one unannounced speaker took the audience by surprise: Pope Francis.

The pope was on a big screen rather than onstage, and his address had been recorded and edited earlier in April, but still: even for non-Catholics, the bishop of Rome has a certain gravitas.

Under pressure from worker advocates and growing consumer awareness, Tyson Foods on Wednesday promised better conditions for employees at its meat-processing plants.

Tiny, 3-D clusters of human brain cells grown in a petri dish are providing hints about the origins of disorders like autism and epilepsy.

An experiment using these cell clusters — which are only about the size of the head of a pin — found that a genetic mutation associated with both autism and epilepsy kept developing cells from migrating normally from one cluster of brain cells to another, researchers report in the journal Nature.

Mexico has long argued that U.S. labeling rules for dolphin-safe tuna unfairly restrict its access to the U.S. market. And in a decision Tuesday, the World Trade Organization agreed, saying Mexico may seek $163 million annually from the U.S. in retaliatory measures.

The controversial labeling rules, aimed at protecting dolphins from getting ensnared in fishing nets and killed, date back to 1990.

Twenty-five years ago this week, four Los Angeles policemen — three of them white — were acquitted of the savage beating of Rodney King, an African-American man. Caught on camera by a bystander, graphic video of the attack was broadcast into homes across the nation and worldwide.

Fury over the acquittal — stoked by years of racial and economic inequality in the city — spilled over into the streets, resulting in five days of rioting in Los Angeles. It ignited a national conversation about racial and economic disparity and police use of force that continues today.

Researchers in Southern California say they've uncovered evidence that humans lived there 130,000 years ago.

If it's true, it would be the oldest sign of humans in the Americas ever — predating the best evidence up to now by about 115,000 years. And the claim has scientists wondering whether to believe it.

A U.S. missile defense system that's now being installed in South Korea will be operational "in the coming days," says Adm. Harry Harris, commander of the U.S. Pacific Command.

For more than four decades, Jonathan Demme threaded a diverse path through the film industry — beginning as a publicist, filming everything from documentaries to comedic sendups, and finally earning the status of Oscar-winning elder statesman. He was 73.

The director died Wednesday in Manhattan from complications of esophageal cancer. His publicist, 42 West, confirmed Demme's death to NPR.

Demme made films such as The Silence of the Lambs and Stop Making Sense that have helped define their respective genres.

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Local News

   ST. LOUIS (AP) - Two children and an adult are injured after their car was struck by an SUV fleeing police near Lambert Airport in St. Louis.

   The crash happened just before 10 a.m. Tuesday on Lambert International Boulevard. Police say a Normandy, Missouri, officer saw an SUV commit a moving violation on Interstate 70 and realized it matched the description of an SUV taken during an armed robbery that occurred hours earlier.